Effects of preoperative magnesium sulphate infusion on the hemodynamics in patients with off-pump coronary artery bypass grafting surgery

Background: Off-pump coronary artery bypass grafting (OPCABG) is an effective method for coronary artery revascularization, but it may lead to unstable hemodynamics. Purpose: To evaluate the effects of preoperative magnesium sulphate infusion on the hemodynamics in patients with OPCABG surgery. Methods: Sixty patients undergoing routine OPCABG surgery were randomly divided into control group (C) and magnesium sulfate group (M), 30 patients in each group. All patients were performed with routine operation preparation and induced anesthesia, followed by OPCABG surgery. Before surgery, M group was intravenously infused with magnesium sulfate (10 mg/ kg), and C group was intravenously infused with 0.9% normal saline with the same volume. The preoperative and intraoperative hemodynamics indexes and intraoperative vasoactive drug use in two groups were recorded and compared. Results: There was no significant differences in gender, age, weight, preoperative hear rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure or mean arterial pressure between two groups (P > 0.05), with no significant differences in surgery time, intraoperative blood loss or central venous pressure (P > 0.05). The intraoperative max SBP, max DBP, SBP fluctuation and DBP fluctuation in M group were significantly lower than C group, respectively (P < 0.05). The intraoperative min HR in M group was significantly higher than C group (P < 0.05), and the HR fluctuation in M group was significantly lower than C group (P < 0.05). The percentage of patients intraoperatively using vasoactive drugs in M group was significantly lower than C group (P < 0.05). Conclusion: Preoperative magnesium sulphate infusion can effectively reduce the hemodynamic fluctuation in patients with OPCABG.